Cytokines and the inception of CD8 T cell responses
نویسندگان
چکیده
منابع مشابه
Cytotoxic T-Cell Markers and Cytokines in Human Papillomavirus 16
Background and Aim: Cervical cancer is the fourth main cause of mortality among women, and annually about half a million new cases are detected in developed countries. Based on oncological studies, human papillomavirus (HPV) is classified into two categories: high-risk type and low-risk type, and most cases are related to the high-risk type of human papillomavirus. HPV 16 and 18 are among the m...
متن کاملRegulation of innate CD8+ T-cell activation mediated by cytokines.
Virus-specific CD8(+) T cells develop the ability to function in an "innate" capacity by responding to a remarkable array of cytokines in a TCR-independent manner. Although several cytokines such as IL-12 and IL-18 have been identified as key regulators of CD8(+) T-cell activation, the role of other cytokines and the ways in which they interact with each other remain unclear. Here, we have used...
متن کاملallograft-specific CD8+ T cell responses
The Rockefeller University Press $30.00 J. Exp. Med. 2014 Vol. 211 No. 2 297-311 www.jem.org/cgi/doi/10.1084/jem.20130902 297 T cell–specific co-stimulation blockade is an attractive alternative to traditional immunosuppression to mitigate unwanted immune responses during transplantation and autoimmunity. Owing to the limited tissue distribution of its targets, T cell co-stimulation blockade of...
متن کاملThe Role of γс Cytokines in T Cell Development, T Cell Homeostasis and CD8+ T Cell Function: A Dissertation
T lymphocytes are essential components of the immune system and as such are continually regulated by a variety of factors. Every step of their development, survival and function is tightly monitored to ensure their abilty to recognize most foreign agents and mount adaptive immune responses during pathogenic infections , while remaining tolerant to self-antigens. Among the many factors that part...
متن کاملModeling the dynamics of neonatal CD8+ T cell responses
Neonates are particularly susceptible to a number of infections, and the neonatal CD8+ T-cell response demonstrates differences in both the phenotype and magnitude of responses to infection compared with adults. However, the underlying basis for these differences is unclear. We have used a mathematical modeling approach to analyze the dynamics of neonatal and adult CD8+ T-cell responses followi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Immunology
سال: 2011
ISSN: 1471-4906
DOI: 10.1016/j.it.2011.01.004